Amphetamine Self-Administration Attenuates Dopamine D2 Autoreceptor Function
نویسندگان
چکیده
منابع مشابه
Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice.
Dopamine (DA) autoreceptors expressed along the somatodendritic extent of midbrain DA neurons modulate impulse activity, whereas those expressed at DA nerve terminals regulate both DA synthesis and release. Considerable evidence has indicated that these DA autoreceptors are of the D2 subtype of DA receptors. However, many pharmacological studies have suggested an autoreceptor role for the DA D3...
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Chronic blockade or activation of dopamine receptors is critical for the pharmacological treatment of diseases like schizophrenia, Parkinson's or attention deficit and hyperactivity disorder. However, the long-term impact of such treatments on dopamine neurons is unclear. Chronic blockade of the dopamine D2 receptor in vivo triggers an increase in the axonal arborization of dopamine neurons [Eu...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2014
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2014.30